53815-60-4

Basic information

• Product Name: 2-(2-METHOXYPHENOXY)ETHYL CHLORIDE
• Synonyms: 2-(2-METHOXYPHENOXY)ETHYL CHLORIDE;CHEMBRDG-BB 9070433;1-(2-CHLOROETHOXY)-2-METHOXYBENZENE;UKRORGSYN-BB BBV-1775314;1-(2-chloroethoxy)-2-methoxybenzene(SALTDATA: FREE);2-Methoxyphenoxyethyl chloride;Guaicol 2-chloroethyl ether;O-(2-Chloroethyl)guaiacol
• CAS NO: 53815-60-4
• Molecular Formula: C₉H₁₁ClO₂
• Molecular Weight: 186.64
• Mol File: 53815-60-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 41-43℃
• Boiling Point: 251℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.128
• Vapor Pressure: 0.0328mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-(2-METHOXYPHENOXY)ETHYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXYPHENOXY)ETHYL CHLORIDE(53815-60-4)
• EPA Substance Registry System: 2-(2-METHOXYPHENOXY)ETHYL CHLORIDE(53815-60-4)

Safety Data

• Hazardous Substances Data: 53815-60-4(Hazardous Substances Data)

Usage

Uses

1-(2-Chloroethoxy)-2-methoxy benzene, is an impurity of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.

InChI:InChI=1/C9H11ClO2/c1-11-8-4-2-3-5-9(8)12-7-6-10/h2-5H,6-7H2,1H3

Upstream product

• 90-05-1 2-methoxy-phenol 
• 107-04-0 1-Bromo-2-chloroethane 
• 80-41-1 2-chloroethyl tosylate 
• 107-06-2 1,2-dichloro-ethane 
• 18181-71-0 2-(2-methoxyphenoxy)ethanol 

Downstream Products

• 10587-65-2 2-[2-(2-methoxy-phenoxy)-ethylamino]-ethanol 
• 10476-36-5 [2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(2-methoxy-phenoxy)-ethyl]-amine 
• 438195-07-4 5-Fluoro-3-{1-[2-(2-methoxyphenoxy)ethyl]-piperidin-4-ylmethyl}-1 H-indole 
• 72956-09-3 carvedilol 
• 7784-99-8 1-methoxy-2-vinyloxybenzene 
• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 1393910-27-4 C₃₃H₄₄N₄O₃S₂ 
• 1393910-26-3 C₃₃H₄₂N₄O₅S₂ 
• 1393907-12-4 8-methoxy-9-[2-(4-phenylpiperazino)ethoxy]-(13aS)-1,2,3,13a-tetrahydro-5H-pyrrolo[2,1-c][1,4]naphthodiazepin-5-one 
• 1393910-25-2 C₃₄H₄₆N₄O₃S₂ 
• 1393910-24-1 C₃₄H₄₄N₄O₅S₂ 
• 1393907-11-3 8-methoxy-9-[2-(4-benzylpiperazino)ethoxy]-(13aS)-1,2,3,13a-tetrahydro-5H-pyrrolo[2,1-c][1,4]naphthodiazepin-5-one 
• 180987-80-8 5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one 
• 1218777-36-6 C₁₂H₁₇NO₄ 

Relevant articles and documents

Preparation method for 2-(2-methoxyphenoxy)ethylamine

The invention provides a preparation method for 2-(2-methoxyphenoxy)ethylamine. The preparation method comprises the following steps: synthesizing 2-(2-methoxyphenoxy)ethanol with guaiacol as a starting material; then synthesizing 2-(2-methoxyphenoxy)chloroethane through chlorination; then reacting 2-(2-methoxyphenoxy)chloroethane with potassium phthalimide to obtain N-(o-methoxyphenoxyethyl)-phthalimide; and finally, performing basic hydrolysis to obtain 2-(2-methoxyphenoxy)ethylamine. The yields of the above four steps of reactions are that the yield of 2-(2-methoxyphenoxy)ethanol is 98.9%;the yield of 2-(2-methoxyphenoxy)chloroethane is 93.7%; the yield of N-(o-methoxyphenoxyethyl)-phthalimide is 86.4%; the yield of 2-(2-methoxyphenoxy)ethylamine is 91.2%; and the total yield of the four steps is 73.04%, which is higher than the yield of 43% in conventional production processes. The preparation method of the invention reduces the production cost of 2-(2-methoxyphenoxy)ethylamine and is safe in the production process.

Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof

The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl

A facile synthesis of carvedilol via β-amino alcohol intermediate

A facile synthesis of Carvedilol via a key β-amino alcohol intermediate is described and this approach avoids the formation of bis side product (impurity B).