53826-89-4

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-5,7-dihydrothieno[3,4-d]pyrimidine serves as a crucial building block in the synthesis of a variety of drug molecules. Its application is primarily driven by its potential to contribute to the development of pharmaceuticals aimed at treating a range of medical conditions, including but not limited to cancer, inflammation, and infectious diseases.
Used in Research Laboratories:
In research settings, 4-chloro-5,7-dihydrothieno[3,4-d]pyrimidine is utilized for the synthesis of novel compounds that possess potential pharmacological activities. Its role in laboratory research is instrumental in advancing the discovery and understanding of new therapeutic agents.
Used in Organic Synthesis:
Due to its distinctive structural attributes, 4-chloro-5,7-dihydrothieno[3,4-d]pyrimidine is an important intermediate in organic synthesis. It plays a key role in the creation of complex organic molecules that can have applications in various fields, including but not limited to pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C6H5ClN2S/c7-6-4-1-10-2-5(4)8-3-9-6/h3H,1-2H2

Upstream product

• 78647-31-1 Methyl tetrahydro-4-oxo-3-thiophenecarboxylate 
• 5719-29-9 5,7-dihydrothieno[3,4-d]pyrimidin-4-ol 
• 5719-29-9 5,7-dihydro-3H-thieno[3,4-d]pyrimidin-4-one 

Downstream Products

• 1001125-09-2 (R)-tert-butyl 3-(4-chlorophenyl)-1-(4-(6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 
• 1001125-13-8 (R)-tert-butyl 3-(4-chlorophenyl)-1-(4-(6-oxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 
• 1001124-44-2 tert-butyl (R)-3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 

Relevant academic research and scientific papers

DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.