538374-56-0Relevant academic research and scientific papers
Synthesis of new camptothecin analogs with improved antitumor activities
Niizuma, Satoshi,Tsukazaki, Masao,Suda, Hitomi,Murata, Takeshi,Ohwada, Jun,Ozawa, Sawako,Fukuda, Hiroshi,Murasaki, Chikako,Kohchi, Masami,Morikami, Kenji,Yoshinari, Kiyoshi,Endo, Mika,Ura, Masako,Tanimura, Hiromi,Miyazaki, Yoko,Takasuka, Tsuyoshi,Kawashima, Akira,Nanba, Eitaro,Nakano, Kounosuke,Ogawa, Kotaro,Kobayashi, Kazuko,Okabe, Hisafumi,Umeda, Isao,Shimma, Nobuo
scheme or table, p. 2018 - 2021 (2009/11/30)
Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared from 9-n
Novel hexacyclic compounds
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, (2008/06/13)
The present invention relates to hexacyclic compound of the formula [1], wherein Z, R3 and R4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of cell proliferative disorders.
