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CAS

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53840-59-8

O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 53840-59-8 Structure

  • Basic information

    1. Product Name: O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride
    2. Synonyms: O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride
    3. CAS NO:53840-59-8
    4. Molecular Formula:
    5. Molecular Weight: 427.839
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 53840-59-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride(53840-59-8)
    11. EPA Substance Registry System: O3,O4,O6-triacetyl-2-benzoylamino-α-D-2-deoxy-glucopyranosyl chloride(53840-59-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 53840-59-8(Hazardous Substances Data)

53840-59-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 53840-59-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,8,4 and 0 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 53840-59:
(7*5)+(6*3)+(5*8)+(4*4)+(3*0)+(2*5)+(1*9)=128
128 % 10 = 8
So 53840-59-8 is a valid CAS Registry Number.

53840-59-8Relevant articles and documents

Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives

Horita, Yasuhiro,Takii, Takemasa,Kuroishi, Ryuji,Chiba, Taku,Ogawa, Kenji,Kremer, Laurent,Sato, Yasuo,Lee, Yoosa,Hasegawa, Tomohiro,Onozaki, Kikuo

, p. 899 - 903 (2011)

The present study was undertaken to optimize the anti-tubercular activity of 2-acetamido-2-deoxy-β-d-glucopyranosyl N,N-dimethyldithiocarbamate (OCT313, Glc-NAc-DMDC), a lead compound previously reported by us. Structural modifications of OCT313 included the replacements of the DMDC group at C-1 by pyrrolidine dithiocarbamate (PDTC) and the acetyl group at C-2 by either propyl, butyl, benzyl or oleic acid groups. The antimycobacterial activities of these derivatives were evaluated against Mycobacterium tuberculosis (MTB). Glc-NAc-pyrrolidine dithiocarbamate (OCT313HK, Glc-NAc-PDTC) exhibited the most potent anti-tubercular activity with the minimal inhibitory concentration (MIC) of 6.25-12.5 μg/ml. The antibacterial activity of OCT313HK was highly specific to MTB and Mycobacterium bovis BCG, but not against Mycobacterium avium, Mycobacterium smegmatis, Staphylococcus aureus or Escherichia coli. Importantly, OCT313HK was also effective against MTB clinical isolates, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Interestingly, OCT313HK was exerted the primary bactericidal activity, and it was also exhibited the bacteriolytic activity at high concentrations. We next investigated whether the mycobacterial monooxygenase EthA, a common activator of thiocarbamide-containing anti-tubercular drugs, also activated OCT313HK. Contrary to our expectations, the anti-tubercular activity of dithiocarbamate sugar derivatives and dithiocarbamates were not dependent on ethA expression, in contrast to thiocarbamide-containing drugs. Overall, this study presents OCT313HK as a novel and potent compound against MTB, particularly promising to overcome drug resistance.

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