53846-52-9

Basic information

• Product Name: D-Glucopyranoside,(3â,25R)-spirost-5-en-3-yl O-6-deoxy-L-mannopyranosyl-(1f2)-O-[Dglucopyranosyl-( 1f4)]-
• CAS NO: 53846-52-9
• Molecular Weight: 885.056
• Mol File: 53846-52-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: D-Glucopyranoside,(3â,25R)-spirost-5-en-3-yl O-6-deoxy-L-mannopyranosyl-(1f2)-O-[Dglucopyranosyl-( 1f4)]- (CAS DataBase Reference)
• NIST Chemistry Reference: D-Glucopyranoside,(3â,25R)-spirost-5-en-3-yl O-6-deoxy-L-mannopyranosyl-(1f2)-O-[Dglucopyranosyl-( 1f4)]- (53846-52-9)
• EPA Substance Registry System: D-Glucopyranoside,(3â,25R)-spirost-5-en-3-yl O-6-deoxy-L-mannopyranosyl-(1f2)-O-[Dglucopyranosyl-( 1f4)]- (53846-52-9)

Safety Data

• Hazardous Substances Data: 53846-52-9(Hazardous Substances Data)

Upstream product

• 94992-07-1 (25R)-O-β-D-glucopyranosyl-22-O-methylfurost-5-ene-3β,22ξ,26-triol 3-O-2)-O-<β-D-glucopyranosyl-(1->4)>-β-D-glucopyranoside> 
• 1240293-61-1 (25R)-26-[(β-D-glucopyranosyl)oxy]-22α-hydroxyfurost-5-en-3β-yl O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside 

Downstream Products

• 19057-67-1 ophiopogonin C 
• 14144-06-0 trillin 
• 512-04-9 diosgenin 
• 55639-73-1 (25R)-5-en-spirostane-3β-ol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside 

Relevant articles and documents

Steroidal Glycosides from the Aerial Parts of Avena sativa L. And Their Cytotoxic Activity

Twelve steroidal glycosides (1-12) were isolated from the aerial parts of Avena sativa L. (Poaceae). Among the isolated compounds, 1 was directly isolated from the plant for the first time, and 2-6 were new steroidal glycosides. The structures of 1-6 were determined by analysis of their spectroscopic data, chemical transformations, and chromatographic and spectroscopic analyses of the hydrolyzed products. Compounds 5 and 6 were novel steroidal glycosides with a B-ring contracted skeleton (B-nor steroid). Compounds 1, 9, 11, and 12 were cytotoxic to HL-60 human promyelocytic leukemia cells, MIA PaCa-2 human pancreatic carcinoma cells, and A549 human lung adenocarcinoma cells with IC50 values ranging from 0.79 to 13.5 μM. HL-60 cells treated with 1 exhibited apoptotic characteristics, namely, condensed nuclear chromatin, accumulation of sub-G1 cells, and activation of caspase-3. Additionally, the loss of the mitochondrial membrane potential and the release of cytochrome c into the cytoplasm in 1-treated HL-60 cells suggested that 1 induced apoptosis through a mitochondrial-dependent apoptotic pathway.

Steroidal saponins from the bulbs of Lilium longiflorum and their antitumour-promoter activity

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