53855-47-3Relevant articles and documents
Novel synthesis of fused indoles and 2-substituted indoles by the palladium-catalyzed cyclization of N-cycloalkenyl-o-haloanilines
Maruyama, Jun,Yamashita, Hiromichi,Watanabe, Takeshi,Arai, Shigeru,Nishida, Atsushi
experimental part, p. 1327 - 1335 (2009/04/10)
A new palladium-catalyzed cyclization of N-alkenyl-o-haloanilines with selective isomerization of a double bond followed by formal 5-endo-trig cyclization was developed. A variety of fused and 2-substituted indoles were synthesized from enaminoesters prepared by condensation of β-ketoesters and o-iodoaniline.
Fischer Indole Synthesis of 3-Acyl and 3-Alkoxy-carbonylindoles
Mills, Keith,Khawaja, Ibtisam K. Al,Al-Saleh, Fowzia,Joule, John A.
, p. 636 - 641 (2007/10/02)
N-Benzyl-N-phenylhydrazine derivatives of 1,3-diketones and 1,3-ketoesters undergo normal Fischer cyclisations to indoles, but no method could be found for the subsequent removal of the N-protecting group.No method could be found for the indolisation of N-aroyl-N-phenylhydrazine derivatives of dimedone with retention of the N-protecting group, though heating in tetralin did effect the electrocyclic step of the Fischer sequence and the formation of a carbon-carbon bond.
