53865-18-2Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted and 11- or 12-substituted Δ8-tetrahydrocannabinol
Compton,Little,Martin,Gilman,Saha,Jorapur,Sard,Razdan
, p. 1437 - 1443 (2007/10/02)
The synthesis of a variety of novel 10-substituted cannabidiol (CBD) and 11- or 12-substituted Δ8-tetrahydrocannabinol (Δ8-THC) analogues containing amino, alkylamino, azido, or a N,N-bis(2-chloroethyl)amino functional group is descr
The synthesis of some 11-substituted tetrahydrocannabinol metabolites
ApSimon, John W.,Collier, T. Lee,Guiver, Michael D.
, p. 2804 - 2809 (2007/10/02)
9-Bromo-11-oxo-hexahydrocannabinol (5) was prepared from the ketocannabinoid 3b via the epoxysulfone 4.The dehydrobromination of the bromoaldehyde 5 could be controlled to give either the thermodinamically more stable Δ8-aldehyde 2c, or the Δ9-aldehyde 1c by an intramolecularly assisted elimination.Reduction of the unsaturated aldehydes gave the allylic alcohol metabolites 2a and 1a, respectively.
