53868-02-3

Basic information

• Product Name: 8-AMinoquinolin-2(1H)-one
• Synonyms: 8-AMinoquinolin-2(1H)-one
• CAS NO: 53868-02-3
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.17262
• Mol File: 53868-02-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 417.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.287±0.06 g/cm3(Predicted)
• PKA: 11.35±0.70(Predicted)
• CAS DataBase Reference: 8-AMinoquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-AMinoquinolin-2(1H)-one(53868-02-3)
• EPA Substance Registry System: 8-AMinoquinolin-2(1H)-one(53868-02-3)

Safety Data

• Hazardous Substances Data: 53868-02-3(Hazardous Substances Data)

Usage

General Description

8-Aminoquinolin-2(1H)-one, also known as 8-AQ, is a chemical compound with the molecular formula C9H8N2O. It is an organic compound with a quinoline backbone and an amino group at the 8th position. 8-AQ has been studied for its potential pharmaceutical applications, particularly in the field of antimalarial drugs. It has shown promise as a potential anti-malarial agent due to its ability to inhibit the growth of the malaria parasite. Additionally, 8-AQ has also been studied for its potential use in other therapeutic applications, such as in the treatment of neurodegenerative diseases. Overall, 8-Aminoquinolin-2(1H)-one is a compound of interest in the field of medicinal chemistry and drug development.

Upstream product

• 4225-86-9 2-chloro-8-nitroquinoline 
• 612-62-4 2-Chloroquinoline 
• 81840-10-0 2-acetylamino-β-ethoxyacryloanilide 
• 34801-09-7 N-(2-aminophenyl)acetamide 
• 81840-11-1 8-acetylamino-2(1H)-quinolinone 
• 7461-12-3 8-Nitroquinolin-2(1H)-one 

Downstream Products

• 266336-56-5 2-Cyano-4H-imidazo[4,5,1-ij]quinoline-4-one 

Relevant articles and documents

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift

Among a series of benzopyridone-based scaffolds investigated as human transient receptor potential vanilloid 1 (TRPV1) ligands, two isomeric benzopyridone scaffolds demonstrated a consistent and distinctive functional profile in which 2-oxo-1,2-dihydroquinolin-5-yl analogues (e.g., 2) displayed high affinity and potent antagonism, whereas 1-oxo-1,2-dihydroisoquinolin-5-yl analogues (e.g., 3) showed full agonism with high potency. Our computational models provide insight into the agonist-antagonist boundary of the analogues suggesting that the Arg557 residue in the S4-S5 linker might be important for sensing the agonist binding and transmitting signals. These results provide structural insights into the TRPV1 and the protein-ligand interactions at a molecular level.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.