53871-06-0Relevant articles and documents
Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders
Morley, Andrew,Tomkinson, Nicholas,Cook, Andrew,MacDonald, Catherine,Weaver, Richard,King, Sarah,Jenkinson, Lesley,Unitt, John,McCrae, Christopher,Phillips, Tim
, p. 6031 - 6035 (2011/11/06)
To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.
Process for preparing phenoxypyridine derivatives
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Page/Page column 14, (2008/12/08)
A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.
Novel aminoglycoside derivatives
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, (2008/06/13)
Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: STR1 (wherein R is 4 to 6 membered heterocyclic group containing 1 to 2 nitrogen atoms whi
