53883-61-7

Usage

Uses

Used in Chemical Synthesis:
P-fluorophenyltriMethoxysilane is used as a coupling agent in the synthesis of various organic compounds. Its ability to form stable bonds with different molecules makes it a valuable component in creating new chemical entities.
Used in Material Production:
In the production of materials such as polymers and glass, P-fluorophenyltriMethoxysilane is used as a surface modifier. It enhances the properties of these materials by altering their surface characteristics, leading to improved performance and durability.
Used in Pharmaceutical Development:
P-fluorophenyltriMethoxysilane is utilized as a building block in the development of pharmaceuticals. Its unique structure allows it to be incorporated into drug molecules, potentially leading to the creation of new therapeutic agents.
Used in Agrochemical Development:
Similarly, in the agrochemical industry, P-fluorophenyltriMethoxysilane is used as a building block for the development of new agrochemicals. Its incorporation into these compounds can contribute to the creation of more effective and targeted products for agricultural use.
Safety Precautions:
It is crucial to handle P-fluorophenyltriMethoxysilane with care, as it is hazardous if inhaled, swallowed, or comes into contact with the skin. Proper protective measures, including the use of personal protective equipment and handling in well-ventilated areas, should be taken to ensure the safety of individuals working with this chemical compound.

Upstream product

• 681-84-5 tetramethylorthosilicate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 53883-56-0 p-fluorophenylsilatranone 
• 324-74-3 4-fluoro-biphenyl 
• 2972-90-9 4,α, β,β-tetrafluoroethenylbenzene 
• 1310708-94-1 2-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 366-63-2 4-fluoro-N-phenylbenzamide 
• 1140233-93-7 N-[4-(fluoro)phenyl]-S-methyl-S-phenylsulfoximine 
• 114260-45-6 1-(4-fluoro-phenyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane 

Relevant academic research and scientific papers

Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis

We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.

Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes

We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.

Carbon-Silicon Bond Formation in the Synthesis of Benzylic Silanes

Sterically encumbered organosilanes can be difficult to synthesize with conventional, strongly basic reagents; the harsh reaction conditions are often low yielding and not suitable for many functional groups. As an alternative to the typical anionic strat