53888-89-4Relevant academic research and scientific papers
Synthesis of Phosphalilolidine and Phosphajulolidine
Chen, Chin H.,Brighty, Katherine E.,Michaels, Frank M.
, p. 361 - 367 (1981)
The successful syntheses and characterizations of the novel bicyclic C-P heterocycles 1,1,5,5,8-pentamethylphosphalilolidine (3) and 1,1,6,6,8-pentamethylphosphajulolidine (4) are described.Cyclization of 1-(methyl-p-tolylphosphinoyl)-3-methylbutan-2-ol (7) by using polyphosphoric acid at 120 deg C produced an inseparable, isomeric mixture (83percent yield) of 1,4,4,7- and 1,4,4,6-tetramethylphosphinoline oxides (8 and 9) in ratio of ca. 3:1.This isomerization is rationalized by a mechanism which involves the cationic ipso cyclization followed by migration of the phosphinoyl group.Cyclic voltammetric and UV spectroscopic data suggest that both phosphajulolidine and phosphalilolidine have essentially no n-? interaction between the lone-pair electrons on the phosphorus and the adjacent aromatic ? system.
Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
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, (2008/06/13)
The invention relates to compounds of the general formula: in which RA-RC and W are as defined herein, and to their preparation and use.
Novel pyridopyrimidones and uses thereof
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, (2008/06/13)
This invention relates to compounds of the general formula: in which RA, RB and RC are as defined herein, and to their preparation and use.
Novel indolinones and uses thereof
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, (2008/06/13)
This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.
Novel quinolinones and uses thereof
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, (2008/06/13)
The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q,
Novel quinolines and uses thereof
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, (2008/06/13)
This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
Novel quinazolines and uses thereof
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, (2008/06/13)
This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
