53898-02-5Relevant academic research and scientific papers
Visible Light Promoted β-C—H Alkylation of β-Ketocarbonyls via a β-Enaminyl Radical Intermediate
Wang, Dehong,Zhang, Long,Luo, Sanzhong
, p. 311 - 320 (2018/02/21)
A 5πe carbonyl activation mode is reported on the basis of photo-induced single-electron-transfer (SET) oxidation of a secondary enamine. The resultant β-enaminyl radical intermediate was trapped by a wide range of Michael acceptors, producing β-alkylation products of β-ketocarbonyls in a highly efficient manner.
PROCESS FOR THE PREPARATION OF RAMIPRIL
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Page/Page column 33; 34; 40, (2016/01/01)
An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.
Efficient synthesis of β-aminoacrylates and β-enaminones catalyzed by Zn(OAc)2·2H2O
Vohra, Ramandeep Kaur,Renaud, Jean-Luc,Bruneau, Christian
, p. 1943 - 1952 (2007/10/03)
The direct condensation of amines with β-ketoesters and β-diketones to produce functional enamine derivatives has been investigated with zinc Lewis acid catalysts. Zn(OAc)2·2H2O shows good catalytic activity and leads to a chemo- and stereoselective formation of (Z)-enamine derivatives from aliphatic primary amines and ring-substituted anilines under mild conditions.
