539-23-1

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Amino-2-butoxypyridine is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for versatile chemical modifications, facilitating the creation of diverse medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 5-Amino-2-butoxypyridine serves as an intermediate in the production of various agrochemicals, such as pesticides and herbicides. Its incorporation enhances the effectiveness and selectivity of these compounds, promoting sustainable agricultural practices.
Used in Fine Chemicals Synthesis:
5-Amino-2-butoxypyridine is employed as a key intermediate in the synthesis of fine chemicals, which are high-purity specialty chemicals used in various applications, including fragrances, dyes, and advanced materials.
Used as a Chelating Agent:
5-Amino-2-butoxypyridine functions as a chelating agent, capable of forming stable complexes with metal ions. This property is valuable in various applications, such as water treatment, metal extraction, and the stabilization of catalysts.
Used in Coordination Chemistry:
In coordination chemistry, 5-Amino-2-butoxypyridine acts as a ligand, forming coordination complexes with metal ions. These complexes exhibit unique properties and are of interest in areas such as catalysis, materials science, and supramolecular chemistry.
Used in Medicinal Chemistry and Drug Development:
5-Amino-2-butoxypyridine holds potential in medicinal chemistry and drug development, where it can be used to design and synthesize novel bioactive molecules with potential therapeutic applications.
Overall, 5-Amino-2-butoxypyridine is a multifaceted chemical compound with a wide range of applications in different industries, showcasing its significance in modern chemical research and development.

InChI:InChI=1/C9H14N2O/c1-2-3-6-12-9-5-4-8(10)7-11-9/h4-5,7H,2-3,6,10H2,1H3

Upstream product

• 4487-59-6 2-bromo-5-nitropyridine 
• 71-36-3 butan-1-ol 
• 6627-95-8 2-butoxy-5-nitro-pyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 1393108-04-7 N-benzyl-6-butoxypyridin-3-amine 

Downstream Products

• 108720-23-6 N-(6-butoxy-pyridin-3-yl)-phthalimide 
• 71-41-0 pentan-1-ol 
• 6940-93-8 2-((6-butoxypyridin-3-yl)amino)-4-chlorobenzoic acid 
• 99387-22-1 (6-Butoxy-pyridin-3-yl)-(4-ethoxy-phenyl)-diazene 
• 75851-93-3 sulfanilic acid-(6-butoxy-[3]pyridylamide) 

Relevant academic research and scientific papers

Preparation of highly reactive pyridine- and pyrimidine-containing diarylamine antioxidants

We recently reported a preliminary account of our efforts to develop novel diarylamine radical-trapping antioxidants (Hanthorn, J. J. et al. J. Am. Chem. Soc. 2012, 134, 8306-8309) wherein we demonstrated that the incorporation of ring nitrogens into diphenylamines affords compounds which display a compromise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation. Herein we provide the details of the synthetic efforts associated with that report, which have been substantially expanded to produce a library of substituted heterocyclic diarylamines that we have used to provide further insight into the structure-reactivity relationships of these compounds as antioxidants (see the accompanying paper, DOI: 10.1021/jo301012x). The diarylamines were prepared in short, modular sequences from 2-aminopyridine and 2-aminopyrimidine wherein aminations of intermediate pyri(mi)dyl bromides and then Pd-catalyzed cross-coupling reactions of the amines and precursor bromides were the key steps to yield the diarylamines. The cross-coupling reactions were found to proceed best with Pd(η3-1-PhC3H 4)(η5-C5H5) as precatalyst, which gave higher yields than the conventional Pd source, Pd2(dba) 3.

PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS

Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.

Liquid Crystalline Compounds Bearing Pyridine Ring: 3-(4-Alkoxyphenylazoxy)-6-alkoxypyridines

3-(4-Alkoxyphenylazo)-6-alkoxypyridines (6) with n-alkoxyl (C1-C6) groups were synthesized by the coupling reaction of phenol with 6-alkoxy-3-pyridine diazonium chloride prepared from 2-chloro-5-nitropyridine via 2-alkoxy-5-nitro and 2-alkoxy-5-aminopyridines and subsequent etherification with n-alkyl iodides.Mild oxidation of 6 with hydrogen peroxide in acetic acid provided 3-6-alkoxy-pyridines (7) containing nearly equimolar amounts of ONN (8) and NNO (8') isomers.Centrifugal liquid chromatography satisfactorily separated these two isomers.Mesomorphic behaviors of 8 and 8' are characteristic in that the pyridine ring exerts polar effects and 8 are more balanced in polarity than 8'.Compounds 7 possess rather lower mesomorphic ranges than 8 and 8'.Some of compounds 6 indicate mesomorphic ranges but generally azo compounds are inferior to azoxy ones.