53911-34-5

Basic information

• Product Name: 2-PHENYL-4-PROPYLPYRIDINE
• Synonyms: 2-PHENYL-4-PROPYLPYRIDINE
• CAS NO: 53911-34-5
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Mol File: 53911-34-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYL-4-PROPYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-4-PROPYLPYRIDINE(53911-34-5)
• EPA Substance Registry System: 2-PHENYL-4-PROPYLPYRIDINE(53911-34-5)

Safety Data

• Hazardous Substances Data: 53911-34-5(Hazardous Substances Data)

Upstream product

• 6728-26-3 (E)-2-Hexenal 
• 19433-17-1 acetophenone O-acetyloxime 
• 1122-81-2 4-n-propylpyridine 
• 591-51-5 phenyllithium 

Downstream Products

• 80635-51-4 6-Phenyl-4-propyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide 
• 80636-11-9 6-Phenyl-4-propyl-pyridine-2-carboxylic acid 

Relevant articles and documents

Metal-Free Assembly of Polysubstituted Pyridines from Oximes and Acroleins

Transition-metal-catalyzed synthesis of N-heterocycles from oximes has been previously well established. In this paper, for the first time a metal-free protocol with the combinational employment of iodine and triethylamine has been demonstrated to be effective to trigger the oxime-based synthesis of pyridines with high chemo-selectivity and wide functional group tolerance. A broad range of functional pyridines were prepared in moderate to excellent yields. While neither iodine nor triethylamine could trigger this transformation, mechanistic experiments indicated a radical pathway for the reaction. The resultant 2-aryl-substituted pyridines have been proved to be versatile building blocks in a range of transition-metal-catalyzed C-H functionalization reactions. (Chemical Equation Presented).