53912-20-2Relevant academic research and scientific papers
TiCl 4 -Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions
Ponra, Sudipta,Nyadanu, Aude,Maurin, Sylvie,El Ka?m, Laurent,Grimaud, Laurence,Vitale, Maxime R.
, p. 1331 - 1342 (2017/12/26)
The isocyanide insertion into sulfanyl-phthalides under Lewis acid conditions is reported with full details. This sequential three-component reaction affords a new straightforward and highly convenient method for the preparation of 3-amino-4-sulfanyl isocoumarins, the potential of which is still unexplored.
Hauser–Kraus Annulation of Phthalides with Nitroalkenes for the Synthesis of Fused and Spiro Heterocycles
Kumar, Tarun,Satam, Nishikant,Namboothiri, Irishi N. N.
supporting information, p. 3316 - 3321 (2016/07/26)
Hauser–Kraus annulation of sulfonylphthalides with simple conjugated nitroalkenes follows the expected pathway to furnish naphthoquinones in moderate yields. However, a strategic variation of this reaction by employing nitroalkenes bearing an additional nucleophilic site results in [4+4] annulation leading to complex fused and spiro heterocycles in high yields with high selectivity through a cascade process involving Michael addition, Dieckmann cyclization, and a series of eliminations and rearrangements.
