53917-46-7Relevant academic research and scientific papers
Efficient synthesis of conformationally constrained, amino- triazoloazepinone-containing di- and tripeptides via a one-pot Ugi-Huisgen tandem reaction
Barlow,Jida,Tourwe,Ballet
, p. 6986 - 6989 (2014/10/15)
Herein we describe a catalyst-free procedure employing an Ugi-4CR between a β-azido-α-amino acid, propargylamine, an isocyanide and an aldehyde, followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library of amino-triazoloazepinone-bearing di- and tripeptides with up to four points of diversification and high atom economy. This journal is the Partner Organisations 2014.
