53930-84-0Relevant academic research and scientific papers
Ortho lithiation-in situ borylation of substituted morpholine benzamides
Cederbalk, Anna,Lysén, Morten,Kehler, Jan,Kristensen, Jesper L.
, p. 1576 - 1582 (2017/03/08)
Morpholine amides are cheap and safe alternative to Weinreb amides as acylating agents of organometallic species. Herein, the in-situ lithiation/borylation of 18 ortho- meta- and para-substituted morpholine benzamides has been investigated. 10 of the 18 substrates provided the desired boronic esters as the major isomer (>90% regioselectivity) in crude isolated yields ranging from 68 to 93%. The synthetic usability of such building blocks was subsequently illustrated via the synthesis of a kinase inhibitor.
Synthesis of functionalized carbamates and quinones via sequential oxidation of salicylaldehydes using TBHP as the oxidant
Rajendra Prasad,Suresh,Ravikumar,Reddy, N. Veera,Reddy, K. Rajender
supporting information, p. 6307 - 6310 (2014/12/10)
A sequential oxidative approach was designed to functionalize salicylaldehyde derivatives and provide corresponding bi-functional amide-carbamate and amide-quinone units. A combination of metal/metal free conditions and TBHP as the external oxidant provid
