53937-02-3

Basic information

• Product Name: 4-BENZYLOXY-2(1 H)-PYRIDONE
• Synonyms: 4-BENZYLOXY-2(1 H)-PYRIDONE;4-(benzyloxy)pyridin-2(1h)-one;4-(Benzyloxy)-1,2-dihydropyridine-2-one;4-(Benzyloxy)pyridine-2(1H)-one;4-Benzyloxypyridin-2-one;diethyl-[2-[[2-keto-2-(o-toluidino)ethyl]-methyl-ammonio]ethyl]ammonium dichloride;diethyl-[2-[methyl-[2-(2-methylanilino)-2-oxoethyl]azaniumyl]ethyl]azanium dichloride;diethyl-[2-[methyl-[2-[(2-methylphenyl)amino]-2-oxo-ethyl]azaniumyl]ethyl]azanium dichloride
• CAS NO: 53937-02-3
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22
• EINECS: 1312995-182-4
• Product Categories: Pyridines;Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks
• Mol File: 53937-02-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 201-203 °C(lit.)
• Boiling Point: 464.3 °C at 760 mmHg
• Flash Point: 234.6 °C
• Appearance: Yellow to orange to brown/Powder
• Density: 1.2 g/cm³
• Vapor Pressure: 8.48E-09mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.09±0.10(Predicted)
• CAS DataBase Reference: 4-BENZYLOXY-2(1 H)-PYRIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXY-2(1 H)-PYRIDONE(53937-02-3)
• EPA Substance Registry System: 4-BENZYLOXY-2(1 H)-PYRIDONE(53937-02-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 53937-02-3(Hazardous Substances Data)

Usage

Uses

4-Benzyloxy-2(1H)-pyridone may be used for the synthesis of novel 2-pyridone derivatives. It may be used for the alkylation of the pyridine nitrogen under mild and anhydrous conditions, via reaction with n-Bu4I and KOBu-t.

General Description

N-alkylation of 4-benzyloxy-2(1H)-pyridone with the corresponding benzyl halides has been reported.

InChI:InChI=1/C12H11NO2/c14-12-8-11(6-7-13-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,13,14)

Upstream product

• 2683-66-1 4-benzyloxypyridine-N-oxide 
• 626-03-9 4-hydroxy-2-pyridone 
• 100-39-0 benzyl bromide 
• 77149-75-8 5-benzyloxy-2-azabicyclo<2.2.0>hex-5-en-3-one 

Downstream Products

• 95306-61-9 4-Benzylamino-2-oxo-1,2-dihydropyridine 
• 864757-73-3 4-benzyloxy-1-{4-[tert-butyl(dimethyl)silyloxy]phenyl}-1H-pyridin-2-one 
• 586372-64-7 4-(benzyloxy)-1-(4-methylbenzyl)pyridin-2(1H)-one 
• 586375-09-9 4-[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]benzonitrile 
• 586387-06-6 C₁₄H₁₅NO₂ 
• 586372-72-7 4-benzyloxy-1-(3-fluorobenzyl)-1H-pyridin-2-one 
• 1104442-01-4 4-(benzyloxy)-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 
• 1104453-20-4 4-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-3-fluorobenzonitrile 
• 1104448-45-4 4-(benzyloxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)-pyridin-2(1H)-one 
• 626-03-9 4-hydroxy-2-pyridone 
• 1187743-67-4 4-benzyloxy-1-[3-(1-methylazetidin-3-yl)-1H-indol-6-yl]-1H-pyridin-2-one 
• 1260399-85-6 tert-butyl 3-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-5-methyl-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole-11-carboxylate 
• 1260399-23-2 4-(Benzyloxy)-1-(10-methyl-5,6,7,8,9,10-hexahydro-5,8-iminocyclohepta[4,5]pyrrolo[2,3-b]pyridin-2-yl)pyridin-2(1H)-one hydrochloride 
• 1260399-26-5 4-(Benzyloxy)-1-(10,11-dimethyl-5,6,7,8,9,10-hexahydro-5,8-iminocyclohepta[4,5]pyrrolo[2,3-b]pyridin-2-yl)pyridin-2(1H)-one hydrochloride 

Relevant articles and documents

HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS

The present invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; (I) which are inhibitors of WDR5. The present invention also provides pharmaceutical compositions comprising such compounds, compositions comprising such compounds with an additional therapeutic agent and the therapeutic uses of such compounds.

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

The identification and evolution of a series of potent and selective p38 inhibitors is described. p38 inhibitors based on a N-benzyl pyridinone high-throughput screening hit were prepared and their SAR explored. Their design was guided by ligand bound co-

Syntheses and Ring-opening Reactions of 5-Alkoxy- and 5-Acetoxy-3-oxo-2-azabicyclohex-5-enes

The efficient photochemical synthesis of 5-alkoxy- and 5-acetoxy-3-oxo-2-azabicyclohex-5-enes (2a-e and f, g), and a new rearrangement reaction of the former compounds (2a-e) to 6-alkoxy-2-pyridones (3a-e), are reported.