5394-81-0Relevant academic research and scientific papers
Sterically controlled naphthalene homo-oligoamides with novel structural architectures
Prabhakaran, Panchami,Puranik, Vedavati G.,Chandran, Jima N.,Rajamohanan,Hofmann, Hans-Joerg,Sanjayan, Gangadhar J.
, p. 2458 - 2465 (2009)
Herein we report novel naphthalene homo-oligoamides, derived from 4-amino-3-methoxy-naphthalene-2-carboxylic acid and 4-amino-1-methoxy- naphthalene-2-carboxylic acid as monomer building blocks, that display an anti-periplanar arrangement of the naphthyl rings, primarily induced by steric interactions between adjacent groups and functionalities. The Royal Society of Chemistry 2009.
Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition
Xie, Fuchun,Li, Bingbing X.,Xiao, Xiangshu
, p. 380 - 384 (2013/07/26)
An O-Aminated naphthol AS-E was designed as a prodrug to achieve reductive activation and improved aqueous solubility. During the synthesis of this designed compound, a novel transformation from aryl triflates and ethyl acetohydroximate to oxazoles was discovered. Although the initially designed O-Amino naphthol AS-E was not made successfully, the eventually synthesized O-tert-butylamino derivative was found to be biologically inactive, suggesting that reductive N-O cleavage in this compound was not facile due to unfavorable steric and electronic effects.
Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers
Ramesh, Veera V. E.,Roy, Arup,Vijayadas, Kuruppanthara N.,Kendhale, Amol M.,Prabhakaran, Panchami,Gonnade, Rajesh,Puranik, Vedavati G.,Sanjayan, Gangadhar J.
scheme or table, p. 367 - 369 (2011/02/28)
This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature o
