53948-07-5

Usage

Uses

Used in Pharmaceutical Research:
ARISTOLACTAM-AII is used as a model compound for studying the mechanisms of chemical carcinogenesis, aiding in the development of potential treatments and preventive measures against cancer.
Used in Toxicology Studies:
ARISTOLACTAM-AII is utilized in toxicology research to understand the effects of nephrotoxins and carcinogens on the human body, particularly in the context of kidney and urinary tract cancers.
Used in Public Health Efforts:
Efforts are being made to mitigate exposure to ARISTOLACTAM-AII and other aristolactam compounds in order to protect public health, particularly in relation to aristolochic acid nephropathy and associated kidney diseases.

InChI:InChI=1/C16H11NO3/c1-20-15-12(18)7-10-13-11(17-16(10)19)6-8-4-2-3-5-9(8)14(13)15/h2-7,18H,1H3,(H,17,19)

Downstream Products

• 53948-09-7 aristololactam BII 

Relevant academic research and scientific papers

ARISTOLOLACTAMS OF GONIOTHALAMUS SESQUIPEDALIS WALL. REVISED STRUCTURES OF THE 2-OXYGENATED ARISTOLOLACTAMS

Key Word Index-Goniothalamus sesquipedalis; Annonaceae; aristololactams; goniopedaline; (13)C NMR; revised structures of 2-oxygenated aristololactams.Goniopedaline, a new phenathrene lactam, aristololactam A-II and its N,O-diacetyl derivative, taliscanine (second natural occurence), aurantiamide acetate and β-sitosterol and its β-D-glucoside have been isolated from the leaves and twigs of Goniothalamus sesquipedalis.The structure of goniopedaline has been established from its spectral evidence as 10-amino-3-hydroxy-2,4-dimethoxyphenathrene-1-carboxylic acid lactam.The structures of aristololactam CII, CIII, DII and DIII have been revised from the previously suggested 3-hydroxymethyl-2-methoxy derivatives and the 3-carboxy-2-hydroxy derivatives to the 2-hydroxymethyl-3-methoxy derivatives and the 2-carboxy-3-hydroxy derivatives respectively based on a careful analysis of their (13)C NMR spectral data.Thus, goniopedaline is the only 2-oxygenated aristololactam known so far.This constitutes the first report of the phenanthrene lactams from the Goniothalamus genus.