Hydroxy Ibuprofen, a metabolite of Ibuprofen, is a selective cyclooxygenase inhibitor with an IC50 value of 14.9 μM. It effectively inhibits both PGH synthase-1 and PGH synthase-2, showcasing its potential in various pharmaceutical applications.
53949-54-5
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Basic information
- Product Name: Hydroxy Ibuprofen
- Synonyms: 2,4'-(2-Hydroxymethylpropyl)phenylpropionic Acid;4-(3-Hydroxy-2-methylpropyl)-α-methyl-benzeneacetic Acid;2-[4-(3-Hydroxy-2-methylpropyl)phenyl]propionic acid solution;3-Hydroxyibuprofen solution;2-[4-(3-Hydroxy-2-methylpropyl)phenyl]propionic acid;Ibuprofen Impurity 27;HFAIHLSDLUYLQA-UHFFFAOYSA-N
- CAS NO:53949-54-5
- Molecular Formula: C13H18O3
- Molecular Weight: 222.28022
- EINECS: 200-578-6
- Product Categories: Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 53949-54-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: ?20°C
- Solubility: N/A
- BRN: 9848786
- CAS DataBase Reference: Hydroxy Ibuprofen(CAS DataBase Reference)
- NIST Chemistry Reference: Hydroxy Ibuprofen(53949-54-5)
- EPA Substance Registry System: Hydroxy Ibuprofen(53949-54-5)
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Safety Data
- Hazard Codes: Xn,F
- Statements: 22-11
- Safety Statements: 7-16
- RIDADR: UN1170 - class 3 - PG 2 - Ethanol, solution
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 53949-54-5(Hazardous Substances Data)
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53949-54-5 Usage
Uses
Used in Pharmaceutical Industry:Hydroxy Ibuprofen is used as an anti-inflammatory agent for its ability to inhibit PGH synthase-1 and PGH synthase-2, which are key enzymes involved in the production of prostaglandins. This inhibition helps in reducing inflammation and pain, making it a valuable component in the development of medications for conditions like arthritis and other inflammatory disorders.
Additionally, Hydroxy Ibuprofen's role as a cyclooxygenase inhibitor may also contribute to its potential use in the prevention and treatment of certain types of cancer, as COX enzymes have been implicated in tumor growth and progression. Further research would be necessary to explore this application fully.
Check Digit Verification of cas no
The CAS Registry Mumber 53949-54-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,4 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.Calculate Digit Verification of CAS Registry Number 53949-54:
(7*5)+(6*3)+(5*9)+(4*4)+(3*9)+(2*5)+(1*4)=155
155 % 10 = 5
So 53949-54-5 is a valid CAS Registry Number.
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Sigma-Aldrich
(32494) 3-Hydroxyibuprofen VETRANAL™, analytical standard
53949-54-5
32494-10MG
4,065.75CNY
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53949-54-5Upstream product
53949-54-5Downstream Products
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Hydroxy Ibuprofen
