5395-47-1 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROPROPENE is used as an antibacterial agent for its potential to inhibit the growth of gram-positive bacteria such as Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium. Its application in this industry is due to its ability to provide an alternative treatment option for bacterial infections caused by these resistant strains.
Used in Chemical Research:
As a nitrostyrene derivative, 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROPROPENE can be utilized in chemical research for the development of new compounds with potential applications in various fields, including pharmaceuticals, materials science, and agrochemicals. Its unique structure and properties make it a valuable starting material for the synthesis of novel molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 5395-47-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,9 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5395-47:
(6*5)+(5*3)+(4*9)+(3*5)+(2*4)+(1*7)=111
111 % 10 = 1
So 5395-47-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO4/c1-7(11(13)14)5-8-3-4-9(12)10(6-8)15-2/h3-6,12H,1-2H3/b7-5-
5395-47-1Relevant academic research and scientific papers
Exploring nitrostyrene as a scaffold for a new class a of monoamine oxidase inhibitors
Reis, Joana,Oliveira, Catarina,Milhazes, Nuno,Vi?a, Dolores,Borges, Fernanda
, p. 958 - 961 (2013/02/23)
With the ultimate purpose of finding out the structural features that are relevant for MAO inhibitory activity and selectivity towards MAO-B isoform, a series of compounds encompassing a β-nitrostyrene moiety was designed and the in vitro inhibitory activity was evaluated. In the present work, we report the synthesis and the pharmacological evaluation of a series of functionalized derivatives of β-methyl-β-nitrostyrene with distinct substitution patterns in the phenyl ring, namely hydroxyl, methoxy, benzyloxy and methylenedioxy. All the studied compounds were substituted in meta and para positions of the phenyl ring related to the nitrovinyl side chain. The synthesized compounds were evaluated towards both human MAO isoforms, displaying some of them activities in the low micromolar range. Particularly compound 6 (a methylenedioxy derivative) exhibits high potency and selectivity towards MAO-B.
