53967-42-3Relevant academic research and scientific papers
Conversion des Cis- et Trans-Pyrazolines en Pyrazoles Sur Support Mineral Impregne de Nitrate Ferrique ou Cuivrique
Bougrin, Khalid,Soufiaoui, Mohamed,Yazidi, Mohamed El
, p. 4065 - 4068 (2007/10/02)
Pyrazoles are prepared from cis- and trans-pyrazolines with good yield in dichloromethane under mild reaction conditions using the inexpensive clay-supported iron (III) nitrate "Clayfen" or copper (II) nitrate "Claycop".
CYCLOADDITION DE QUELQUES DIARYLNITRILIMINES SUR DIVERSES ARYLIDENE-2 INDANONES-1. REGIO ET DIASTEREOCHIMIES DES SPIROPYRAZOLINES SYNTHETISEES
Kerbal, Abdelali,Tshiamala, Kabula,Vebrel, Joel,Laude, Bernard
, p. 149 - 162 (2007/10/02)
Spiropyrazolines have been synthetized by 1,3-dipolar cycloaddition of some 2-arylidene 1-indanones with diarylnitrilimines.It is shown that ringclosure reaction is regiospecific, yielding stereohomogeneous spiropyrazolines in one step.The relative config
The Regioselectivity in the Formation of Pyrazolines and Pyrazoles from Nitrile Imines
Hassaneen, Hamdi M.,Hilal, Rifaat H.,Elwan, Nehal M.,Harhash, Abdelhamid,Shawali, Ahmad S.
, p. 1013 - 1016 (2007/10/02)
The 1,3-cycloaddition of the nitrile imines 2a-e to the carbon-carbon double bond in benzalacetophenone leads to the formation of 4-phenyl-5-benzoylpyrazolines 3a-e which were converted into 4-phenyl-5-benzoylpyrazoles 5a-e upon treatment with chloranil in xylene.However, the cycloaddition of 2a-e to the carbon-carbon double bond in the enol tautomer of dibenzoylmethane gives the regioisomers 5-phenyl-5-hydroxy-4-benzoylpyrazolines which loose elements of water to yield 4-benzoyl-5-phenylpyrazoles 6a-e.The orientation in these reactions are interpretted in terms of the Frontier Molecular Orbital theory.The structures of the products 3,5 and 6 were substantiated by their chemical reactions and alternate synthesis whereever possible.
