53975-70-5 Usage
General Description
1H-Pyrazolo[3,4-c]pyridin-3(2H)-one is a chemical compound with the molecular formula C8H6N2O. It is a heterocyclic organic compound that contains a pyrazolo-pyridin-3-one structure. 1H-Pyrazolo[3,4-c]pyridin-3(2H)-one is commonly used as an intermediate in the synthesis of various pharmaceutical compounds, agrochemicals, and other organic compounds. It has been studied for its potential biological and pharmacological properties, including its potential as an anti-cancer, anti-inflammatory, and antimicrobial agent. 1H-Pyrazolo[3,4-c]pyridin-3(2H)-one has also been investigated for its potential as a building block in the synthesis of novel organic materials and as a ligand for metal coordination complexes in catalytic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 53975-70-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,7 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53975-70:
(7*5)+(6*3)+(5*9)+(4*7)+(3*5)+(2*7)+(1*0)=155
155 % 10 = 5
So 53975-70-5 is a valid CAS Registry Number.
53975-70-5Relevant articles and documents
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
Westaway, Susan M.,Preston, Alex G. S.,Barker, Michael D.,Brown, Fiona,Brown, Jack A.,Campbell, Matthew,Chung, Chun-Wa,Drewes, Gerard,Eagle, Robert,Garton, Neil,Gordon, Laurie,Haslam, Carl,Hayhow, Thomas G.,Humphreys, Philip G.,Joberty, Gerard,Katso, Roy,Kruidenier, Laurens,Leveridge, Melanie,Pemberton, Michelle,Rioja, Inma,Seal, Gail A.,Shipley, Tracy,Singh, Onkar,Suckling, Colin J.,Taylor, Joanna,Thomas, Pamela,Wilson, David M.,Lee, Kevin,Prinjha, Rab K.
, p. 1370 - 1387 (2016/03/05)
Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the identification of non-carboxylate inhibitors derived from pyrido[3,4-d]pyrimidin-4(3H)-one. A number of exemplars such as compound 41 possess interesting activity profiles in KDM4C and KDM5C biochemical and target-specific, cellular mechanistic assays.
