53984-76-2

Usage

Uses

Used in Medical and Dental Procedures:
(+)-2-Amino-N-(2,6-dimethylphenyl)propanamide monohydrochloride is used as an analgesic and anesthetic agent for medical and dental procedures. It works by blocking the transmission of nerve signals in the body, producing a numbing effect in the targeted area, which helps in reducing pain and discomfort during surgeries or dental treatments.
Used in Research:
(+)-2-Amino-N-(2,6-dimethylphenyl)propanamide monohydrochloride is also used as a research tool in neuroscience studies. It aids in investigating the role of certain receptors and neurotransmitters in pain perception and processing, contributing to a better understanding of pain mechanisms and the development of new pain management strategies.

InChI:InChI=1/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H/t9-;/m0./s1

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 151416-30-7 (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide 
• 86516-39-4 (-)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide 
• 3558-09-6 N-methyl-N-(o-tolyl)propionamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity

Tocainide and related optically active chiral α-aminoanilides were synthesized and tested in vivo via the hot plate test to evaluate their central analgesic action. The aims of the study were to verify if a) the increase in lipophilicity, obtained by the introduction of an alkyl group on the steric center (3f-i), and the replacement of the C=O group with the C=S (10) group as well as the introduction of a methyl or ethyl group on the amidic nitrogen atom (8a-c) would produce an increase in central analgesic efficacy with respect to Tocainide; b) the 2,6-xylidide moiety is crucial for high analgesic activity (3b-e); c) the hydrogen atom bonded to the amidic nitrogen moiety is an essential pharmacophoric element for analgesic activity. Among all the synthesized compounds, 3f showed antinociceptive properties with a good enantioselective index.

Synthesis and anticonvulsant activity of some 2/3- benzoylaminopropionanilide derivatives

In this study, the synthesis and anticonvulsant properties of sixteen 2/3-benzoylaminopropionanilide derivatives were described. Molecular design of the compounds has been based on the modification of lacosamide which is a functionalized amino acid with a novel anticonvulsant activity. The structural confirmation of the title compounds was achieved by spectral and analytical data. The anticonvulsant activity profile of synthesized compounds was determined by maximal electroshock (MES) and subcutaneous metrazole (scMet) seizure tests, whereas their neurotoxicity was examined using rotarod test. All these tests were performed in accordance with the procedures of the Antiepileptic Drug Development (ADD) program. The majority of the compounds were effective in the MES or scMet screening tests. None of the compounds showed neurotoxicity according to the rotarod test at studied doses. Most active compounds in the series were 3, 12 and 13, which bearing 2-methyl, 2-ethyl and 2-isopropyl substituent on the N-phenyl ring, respectively. Georg Thieme Verlag KG Stuttgart - New York.

Process for the preparation of α-aminoacylanilides

A novel process for the preparation of α-aminoacylanilides comprises the treatment of the corresponding α-haloacylanilides with a solution of ammonium carbamate in aqueous ammonia. The process is especially useful in the preparation of certain active cardiac antiarrhythmic agents, such as tocainide.