53997-64-1Relevant academic research and scientific papers
Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods
Hudlicky, Tomas,Duan, Caiming,Reed, Josephine W.,Yan, Fengyang,Hudlicky, Milos,Endoma, Mary Ann,Eger II, Edmond I.
, p. 363 - 367 (2007/10/03)
Synthetic methods, especially those that use bromine trifluoride as a fluorinating agent, are described for the preparation of a number of fluorinated ethyl methyl ethers in good yield and high purity. In all cases, medium-scale syntheses (8-22g) of potentially anesthetic compounds have been accomplished. The compounds are of sufficient purity (>99%) for biological evaluation.
Catalytic Conversion of Fluoroalkyl Alkyl Ethers to Carbonyl Compounds
England, David C.
, p. 4007 - 4008 (2007/10/02)
Fluoroalkyl alkyl ethers are generally available by attack of alkoxide ion on fluoro olefins.In the presence of Lewis acid catalysts, such methyl and ethyl ethers have now been found to lose methyl or ethyl fluoride, respectively, to give fluorinated carbonyl compounds.The carbonyl compounds include acid fluoride, ketone, keto ester, vinyl ketone, acyl ketene, ketene, and acryloyl fluoride.
