54-16-0 Usage
Description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT), a monoamine neurotransmitter that plays a crucial role in various physiological processes, including mood regulation, appetite, and sleep. It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for the detection of neuroendocrine tumors and as an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. It is also associated with conditions such as autism, insomnia, and chronic migraine.
Uses
Used in Neuroendocrine Tumor Detection:
5-HIAA is used as a biomarker for the detection of neuroendocrine tumors. The elevated levels of 5-HIAA in body fluids can indicate the presence of these tumors, aiding in early diagnosis and treatment.
Used in Serotonin Metabolism Quantification:
5-HIAA is used as an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. This helps researchers understand the role of serotonin in various physiological processes and its relationship with different neurological conditions.
Used in Psychiatry and Neurology Research:
5-HIAA is used as a research tool to study the relationship between serotonin metabolism and various psychiatric and neurological disorders, such as autism, insomnia, and chronic migraine. Understanding the role of 5-HIAA in these conditions can lead to the development of targeted therapies and improved patient outcomes.
Used in Diagnostics for Sepiapterin Reductase Deficiency:
5-HIAA is used in the diagnosis of sepiaptin reductase deficiency, a rare genetic disorder that results in low levels of 5-HIAA in cerebrospinal fluid (CSF). Detecting this deficiency can help in the early identification and management of the condition.
Used in Diagnostics for Bipolar Disorder and ADHD:
5-HIAA levels are found to be low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD). It is used as a diagnostic marker to differentiate these conditions and guide appropriate treatment strategies.
Used in Pharmaceutical Industry:
5-HIAA, being a member of the class of indole-3-acetic acids, can be used in the pharmaceutical industry for the development of drugs targeting serotonin-related pathways. Its chemical properties as a beige crystalline powder make it a suitable candidate for further research and drug formulation.
Mechanism of action
The primary
product of the metabolism of serotonin. Formed by the oxidative
deamination of serotonin by monoamine oxidase, presumably
the A isozyme, 5-HIAA is subsequently cleared by an
active transport mechanism. Unlike serotonin, 5-HIAA is not a
neurotransmitter and thus its formation contributes to the termination
of the synaptic actions of serotonin. Inhibition of
monoamine oxidase activity enhances and prolongs the actions
of serotonin.
Check Digit Verification of cas no
The CAS Registry Mumber 54-16-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 4 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 54-16:
(4*5)+(3*4)+(2*1)+(1*6)=40
40 % 10 = 0
So 54-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)/p-1
