54-23-9

Basic information

• Product Name: URIDINE-2-14C
• Synonyms: URIDINE-2-14C;uridine-2-14C mol. wt. 244.2
• CAS NO: 54-23-9
• Molecular Formula: C9H12N2O6
• Molecular Weight: 246.22
• Mol File: 54-23-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /aqueous ethanol solution
• Storage Temp.: −20°C
• CAS DataBase Reference: URIDINE-2-14C(CAS DataBase Reference)
• NIST Chemistry Reference: URIDINE-2-14C(54-23-9)
• EPA Substance Registry System: URIDINE-2-14C(54-23-9)

Safety Data

• Hazard Codes: Xi,R
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2910 7
• Hazardous Substances Data: 54-23-9(Hazardous Substances Data)

Upstream product

• 34340-05-1 [2-14C]zebularine 

Relevant articles and documents

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: Influence of sex and inhibitors

To aid in the clinical evaluation of zebularine, a potential oral antitumor agent, we initiated studies on the metabolism of zebularine in liver cytosol from humans and other mammals. Metabolism by aldehyde oxidase (AO, EC 1.2.3.1) was the major catabolic route, yielding uridine as the primary metabolite, which was metabolized further to uracil by uridine phosphorylase. The inhibition of zebularine metabolism was studied using raloxifene, a known potent inhibitor of AO, and 5-benzylacyclouridine (BAU), a previously undescribed inhibitor of AO. The Michaelis-Menten kinetics of aldehyde oxidase and its inhibition by raloxifene and BAU were highly variable between species.