54-91-1 Usage
Originator
Vercyte ,Abbott ,US ,1966
Manufacturing Process
To a solution of 17.2 g (0.10 mol) of 3-bromopropionyl chloride in 100 ml of anhydrous benzene was added dropwise with stirring a solution of 8.6 g (0.10 mol) of anhydrous piperazine in 20 ml of dry chloroform over a period of 30 minutes. The temperature rose spontaneously to 45°C during the addition. After the temperature ceased to rise, stirring was continued for another hour. The reaction mixture was then filtered to remove the piperazine hydrochloride by-product. The filtrate was evaporated to dryness and the residue recrystallized from ethanol to obtain the desired N,N'-bis-(3bromopropionyl)piperazine as a white crystalline solid melting at 103°C to 104°C. The identity of the product was further established by elemental analysis.
Brand name
Vercyte (Abbott).
Therapeutic Function
Antineoplastic
Safety Profile
Poison by ingestion,subcutaneous and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects.Human mutation data reported. When heated todecomposition it emits very toxic fumes of Br- and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 54-91-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 54-91:
(4*5)+(3*4)+(2*9)+(1*1)=51
51 % 10 = 1
So 54-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
54-91-1Relevant articles and documents
Photocatalytic synthesis method of bromopropylpiperazine compound
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Paragraph 006; 0029; 0035-0036; 0039; 0045; 0048; 0054; ..., (2022/03/16)
The invention discloses a photocatalytic synthesis method of a bromopropyl piperazine compound, which is characterized in that bromopropyl alcohol and piperazine are used as raw materials, and the bromopropyl piperazine compound is prepared through photocatalytic reaction in the presence of an oxygen-containing atmosphere, an organic solvent, alkali and a transition metal oxide/C3N4 composite photocatalyst. The bromopropyl alcohol is used as the raw material, SOCl2 is avoided, and the bromopropyl piperazine compound is prepared in a green and economical manner.