54001-22-8

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE
• Synonyms: 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE;2-(4-Chlorophenyl)-4-methyl-1,3-thiazole-5-carbonyl chloride 95%
• CAS NO: 54001-22-8
• Molecular Formula: C₁₁H₇Cl₂NOS
• Molecular Weight: 272.15
• Mol File: 54001-22-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 180 °C
• Boiling Point: 395.6 °C at 760 mmHg
• Flash Point: 193.1 °C
• Appearance: /
• Density: 1.417 g/cm³
• Vapor Pressure: 1.81E-06mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Keep Under nitrogen
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(54001-22-8)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(54001-22-8)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 54001-22-8(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-4-methyl-1,3-thiazole-5-carbonyl chloride is a chemical compound that belongs to the thiazole class. It has a molecular formula of C10H6Cl2N2OS and a molecular weight of 265.14 g/mol. 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is commonly used in the production of thiazole-based pesticides and drugs due to its strong insecticidal and fungicidal properties. Additionally, it is also utilized as a building block in the preparation of various organic compounds.

InChI:InChI=1/C11H7Cl2NOS/c1-6-9(10(13)15)16-11(14-6)7-2-4-8(12)5-3-7/h2-5H,1H3

Upstream product

• 54001-17-1 2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylic acid 
• 337924-65-9 2-(4-chlorophenyl)-4-methyl-thiazole-5-carboxylic acid methyl ester 
• 54001-12-6 ethyl 2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate 

Downstream Products

• 1272385-21-3 N-allyl-4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxamide 
• 1272385-23-5 4-(dibromomethyl)-2-(4-chlorophenyl)-N-ethylthiazole-5-carboxamide 
• 1272385-25-7 4-(dibromomethyl)-2-(4-chlorophenyl)-N-(prop-2-ynyl)thiazole-5-carboxamide 
• 1272385-27-9 ethyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxylate 
• 1272385-29-1 isopropyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxylate 
• 1272385-31-5 S-ethyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carbothioate 
• 1272385-33-7 S-methyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carbothioate 
• 1272385-42-8 4-(dibromomethyl)-2-(4-chlorophenyl)-N-(2-hydroxyethyl)thiazole-5-carboxamide 
• 1272385-09-7 4-(dibromomethyl)-5-chlorocarbonyl-2-(4-chlorophenyl)thiazole 
• 1272385-11-1 4-(dibromomethyl)-2-(4-chlorophenyl)-N-methoxythiazole-5-carboxamide 
• 1272385-13-3 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxamide 
• 1272385-15-5 4-(dibromomethyl)-2-(4-chlorophenyl)-N,N-dimethylthiazole-5-carboxamide 
• 1272385-17-7 4-(dibromomethyl)-2-(4-chlorophenyl)-N-methylthiazole-5-carboxamide 
• 1272385-19-9 4-(dibromomethyl)-2-(4-chlorophenyl)-N,N-diethylthiazole-5-carboxamide 

Relevant articles and documents

Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins

A series of third-generation analogues of methyl 4-(dibromomethyl)-2-(4- chlorophenyl)thiazole-5-carboxylate (1), which had the most potent antiviral activity among the first- and second-generation compounds, have been synthesized and tested against yellow fever virus using a cell-based assay. The compounds were designed with the objectives of improving metabolic stability, therapeutic index, and antiviral potency. The biological effects of C4 and C5 substitution were examined. The methylthio ester and the dihydroxypropylamide analogues had the best antiviral potencies and improved therapeutic indices and metabolic stabilities relative to the parent compound 1.