54001-63-7

Usage

Uses

Used in Biochemistry and Molecular Biology Research:
4,5-Pyrimidinedicarboxylic acid (9CI) is used as a research chemical for its interactions with nucleic acids and its role in protein synthesis. It aids in understanding the fundamental processes of life at the molecular level, contributing to the advancement of scientific knowledge in these fields.
Used in Chemical Reagent Applications:
As a chemical reagent, 4,5-Pyrimidinedicarboxylic acid (9CI) is employed in various laboratory experiments and procedures. Its properties make it a valuable tool for researchers, enabling them to conduct a wide range of studies and analyses in the fields of biochemistry and molecular biology.
Used in Pharmaceutical Development:
4,5-Pyrimidinedicarboxylic acid (9CI) may also be used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity can be harnessed to develop new drugs or improve existing ones, potentially leading to breakthroughs in medicine and healthcare.

InChI:InChI=1/C6H4N2O4/c9-5(10)3-1-7-2-8-4(3)6(11)12/h1-2H,(H,9,10)(H,11,12)

Upstream product

• 36978-53-7 diethyl pyrimidine-4,5-dicarboxylate 
• 52942-64-0 diethyl(ethoxymethylene)oxalacetate 
• 253-82-7 quinazoline 

Downstream Products

• 154384-89-1 4-(2',5'-difluorobenzoyl)pyrimidine-5-carboxylic acid 
• 26060-79-7 furo<3,4-d>pyrimidine-5,7-dione 

Relevant academic research and scientific papers

The synthesis of 6,9-bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline-, benzo[g]quinazoline- and benzo[g]phthalazine-5,10- diones via regiospecific displacements

The synthesis of 6,9-difluoro substituted benzo[g]quinoxaline-5,10-diones (3A), benzo[g]quinazoline-5,10-diones (3B) and benzo[g]phthalazine-5,10- diones (3C) have been accomplished. Treatment of 3A, 3B or 3C with diamines or N-(t-butoxycarbonyl)ethylenediamine led to the corresponding 6,9- bis[(aminoalkyl)amino]-substituted analogues related to 2A, 2B and 2C, respectively. The mono-substituted derivatives 4h and 4i could be isolated from displacements commencing from 3A. A competitive ring-opening of the pyrimidine ring of 2C occurred during the reaction with N,N- dimethylethylenediamine. Removal of the BOC-protecting group from 2Ac led to the hydrochloride salt 2Ab. A novel synthetic pathway to 6,9- dihydroxybenzo[g]phthalazine-5,10-dione (21a) was developed. Conversion of 21a to the ditosylate 21b was readily accomplished. Treatment of 21b with N,N-dimethylethylenediamine or N-(t-butoxycarbonyl)ethylenediamine led to 2Ca and 2Cc, respectively. Removal of the BOC-protecting group from 2Cc with trifluoroacetic acid followed by ion-exchange led to the hydrochloride salt 2Cb. Treatment of ditosylate 21b with N-(t-butoxycarbonyl)ethylenediamine also led to the mono-substituted analogue 25a along with a small amount of the O-S cleavage product 25b. Treatment of 25a with N,N- dimethylethylenediamine led to the unsymmetrically substituted derivative 25c which was converted into the trifluoroacetate salt 25d.