54005-76-4Relevant academic research and scientific papers
RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
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Paragraph 0195; 0258-0259, (2021/03/19)
Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.
Synthesis of saturated fatty acids 11C (13C)-labelled in the ω-methyl position
Neu, Henrik,Kihlberg, Tor,Langstroem, Bengt
, p. 509 - 524 (2007/10/03)
A method for the preparation of saturated fatty acids 11C (13C)-labelled in the ω-methyl position is described. A highly reactive zerovalent copper complex was prepared from lithium naphtalenide reduced lithium(2-thienyl)iodocuprate. The labelling precursors were obtained by addition of tert-butyl ω-iodocarboxylates to the organocuprate and these were reacted with [11C]methyl iodide to form 11C-labelled, protected intermediates. The tert-butyl ester protecting group was rapidly removed with trifluoroacetic acid, affording fatty acids 11C-labelled in the ω-methyl position. A solid phase extraction method was developed and preceded final HPLC purification. In a typical run starting with 2.75 GBq of [11C]methyl iodide, 375 MBq (66%) [16-11C]palmitic acid was obtained within 46 min from the end of radionuclide production.
