54008-85-4Relevant academic research and scientific papers
Photochemical a-carboxyalkylation of tryptophols and tryptaminesviaC-H functionalization
Hu, Fengchi,Liu, Qinglong,Liu, Yuchang,Pan, Zhiqiang,Shang, Wenbin,Xia, Chengfeng
supporting information, p. 4930 - 4933 (2020/05/13)
A process for the a-carboxyalkylation of tryptophols and tryptamines by the functionalization of C-H bonds under visible light irradiation has been developed. The photochemical strategy activated the C-Br bonds of a-bromo-alkylcarboxylic esters to provide carbon-centered radicals under the catalysis of Ir(iii) photocatalyst and coupled with indole derivatives. This methodology displayed wide functional group tolerance and excellent regioselectivity, and was applied to the late-stage functionalization and preparation of indole-containing hybrids.
Enantioselective intermolecular formal [3 + 3] cycloaddition of 2,3-disubstituted indoles with acrolein
Huang, Jianbiao,Zhao, Long,Liu, Yong,Cao, Weiguo,Wu, Xiaoyu
supporting information, p. 4338 - 4341 (2013/09/24)
An expedient enantioselective synthesis of highly substituted hydrocarbazoles has been realized by an organocatalyzed formal [3 + 3] cycloaddition between acrolein and 2,3-disubstituted indoles. Tricyclic hydrocarbazoles were obtained from a broad range of 2,3-disubstituted indoles and acrolein in good to excellent yields and excellent enantioselectivites.
