54022-99-0

Usage

Uses

Used in Pharmaceutical Industry:
5-[3-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC ACID is used as a chemical intermediate for the development of new drugs, leveraging its trifluoromethyl group to enhance metabolic stability and bioavailability. This property is particularly valuable in the design of drugs targeting various diseases and conditions.
Used in Drug Design:
5-[3-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC ACID is used as a structural component in the design of novel pharmaceutical compounds, where its trifluoromethyl group contributes to the overall activity and efficacy of the drug. The presence of this group can influence the compound's interaction with biological targets, potentially leading to improved therapeutic outcomes.
Used in Organic Synthesis:
5-[3-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC ACID is used as a building block in the synthesis of more complex organic compounds, such as advanced materials, specialty chemicals, and other pharmaceutical agents. Its unique structure and properties make it a valuable component in the development of new and innovative products across various industries.

InChI:InChI=1/C12H7F3O3/c13-12(14,15)8-3-1-2-7(6-8)9-4-5-10(18-9)11(16)17/h1-6H,(H,16,17)/p-1

Upstream product

• 54023-09-5 methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 98-16-8 3-trifluoromethylaniline 
• 52130-30-0 5-[3-(trifluoromethyl)phenyl]furan-2-carbaldehyde 
• 98-01-1 furfural 
• 88-14-2 2-furanoic acid 

Downstream Products

• 61941-90-0 5-(3-(trifluoromethyl)phenyl)furan-2-carbonyl chloride 
• 1202642-80-5 5-(3-trifluoromethyl-phenyl)-furan-2-carboxylic acid 3-ethynyl-5-fluoro-4-methanesulfonylamino-benzylamide 
• 1202642-78-1 5-(3-trifluoromethyl-phenyl)-furan-2-carboxylic acid 3-fluoro-4-methanesulfonylamino-5-methyl-benzylamide 
• 1202642-81-6 5-(3-trifluoromethyl-phenyl)-furan-2-carboxylic acid 3-fluoro-4-methanesulfonylamino-5-vinyl-benzylamide 
• 1242462-19-6 (E)-2-(2-nitrovinyl)-5-(3-(trifluoromethyl)phenyl)furan 
• 1253180-91-4 (E)-methyl 3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylate 
• 304896-45-5 C₂₀H₁₃F₃O₂ 
• 1403473-73-3 N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-[3-(trifluoromethyl)phenyl]-2-furamide 
• 1403473-06-2 N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride 
• 1326532-11-9 5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide 
• 1393456-26-2 C₁₇H₁₀F₃NO₃ 
• 1393456-36-4 C₁₅H₆Cl₃F₃OS 
• 1393456-37-5 C₁₉H₁₀ClF₃OS 
• 1365714-48-2 3,4,5-trimethoxybenzyl 5-(3-trifluoromethylphenyl)-2-furoate 

Relevant academic research and scientific papers

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene

A structure consisting of substituted hydantoin linked to a 5-(halophenyl)furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular-weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-3-yl)methyl] imidazolidin-1-yl}-2-furamide (17) possessed the most potent inhibitory activity against Ca2+-induced mitochondrial swelling. The structural development, synthesis and structure-activity relationship of these compounds are described.

Synthesis of heterocycles from arylation products of unsaturated compounds: XVIII. 5-Arylfuran-2-carboxylic acids and their application in the synthesis of 1,2,4-thiadiazole, 1,3,4-oxadiazole, and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives

Arylation of furan-2-carboxylic acid or its methyl ester with arenediazonium chlorides in the presence of copper(II) chloride gave the corresponding 5-arylfuran-2-carboxylic acids or methyl 5-arylfuran-2- carboxylates. 5-Arylfuran-2-carbonyl chlorides rea

Synthesis of some thiadiazolotriazinone derivatives as possible antimicrobial agents

A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4- triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3- mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agen