54023-20-0Relevant academic research and scientific papers
Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis
Wang, Tianzhang,Chen, Guowei,Lu, Yu-Jing,Chen, Qian,Huo, Yanping,Li, Xianwei
supporting information, p. 3886 - 3892 (2019/07/19)
An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).
Compounds containing N-alpha, beta unsaturated ketone and preparation method and application of compounds
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Paragraph 0077-0083, (2019/06/27)
The invention belongs to the technical field of organic synthesis and particularly relates to compounds containing N-alpha, beta unsaturated ketone and a preparation method and application of the compounds. The preparation method includes: dissolving a co
Fe-Catalyzed enaminone synthesis from ketones and amines
Wu, Wenfeng,Wang, Zhuxian,Shen, Qun,Liu, Qiang,Chen, Huoji
supporting information, p. 6753 - 6756 (2019/07/22)
We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions.
Copper-catalyzed intramolecular oxidative amination of enaminone C-H bond for the synthesis of imidazo[1,2-a]pyridines
Wan, Jie-Ping,Hu, Deqing,Liu, Ying,Li, Luyao,Wen, Chengping
supporting information, p. 2880 - 2883 (2016/06/14)
The intramolecular C-N bond forming cross coupling reactions on the enaminones has been achieved for the synthesis of imidazole[1,2-a]pyridines via copper-catalyzed C(sp2)-H amination. This protocol provides a new route for the synthesis of 2-u
