54025-92-2Relevant academic research and scientific papers
HCK INHIBITORS FOR THE TREATMENT OF FIBROSIS AND CANCER
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Paragraph 00107, (2020/10/20)
Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: Formula I. The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.
Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Kulikov, Alexander S.,Epishina, Margarita A.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 669 - 672 (2018/08/17)
[Figure not available: see fulltext.] A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
