54025-94-4Relevant academic research and scientific papers
Heteropolyacides as green and reusable catalysts for the synthesis of [3,4-b][1,3,4] thiadiazines
Hakimi, Fatemeh,Hassanabadi, Alireza,Tabatabaee, Masoumeh,Heravi, Majid M.
, p. 67 - 71 (2014)
Synthesis of [3,4-b][1,3,4]thiadiazines from the condensation of 4-amino-6-methyl-3-thioxo-1,2,4-triazine-5(2H)-one (AMTTO) or 4-amino-1,4-dihydro-5-methyle-1,2,4-triazole-5-thione (AMTT) with phenacyl bromide in the presence of a catalytic amount of vari
Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Kulikov, Alexander S.,Epishina, Margarita A.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 669 - 672 (2018/08/17)
[Figure not available: see fulltext.] A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines
Song, Ming-Xia,Zhang, Chun-Bo,Deng, Xian-Qing,Sun, Zhi-Gang,Quan, Zhe-Shan
experimental part, p. 769 - 773 (2012/04/18)
Various 6-phenyl-7H-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazine derivatives (3a-3n) were designed keeping in view the wide bioactivities of 1, 2, 4-triazoles and their fused heterocyclic derivatives. All target compounds 3a-3n, characterized by IR, 1H-NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that most of the compounds displayed some degree of anticonvulsant activity. Among them, 6-(4-chlorophenyl)-7H-[1,2, 4]triazolo[3, 4-b][1,3,4]thiadiazine (3h) was the most promising compound with an ED50 value of 40.9 mg/kg and a PI value of 6.5.
Pyrolytic desulfurization ring contraction of condensed thiadiazines as a general route towards pyrazoloazines and pyrazoloazoles with a bridgehead (ring junction) nitrogen atom
Ibrahim, Yehia A.,Al-Awadi, Nouria A.,John, Elizabeth
, p. 10365 - 10374 (2008/12/22)
Pyrolytic conversion of [1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4-ones, [1,3,4]thiadiazino[2,3-b]quinazolin-10-ones and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines into their corresponding pyrazolo[5,1-c][1,2,4]triazin-4-ones, pyrazolo[4,3-b]quinazolin-9-on
Solid acid induced cyclocondensation: A facile, one-pot synthesis of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
Heravi,Bakherad,Rahimzadeh,Bakavoli
, p. 2403 - 2407 (2007/10/03)
7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines are synthesized in good yields by the catalytic action of sulfuric acid adsorbed on sillica gel. Starting from 4-amino-5-substituted-1,2,4-triazole-3-thiones and employing cyclocondensation reaction with α-chlo
