540474-13-3

Upstream product

• 110-62-3 pentanal 
• 532-27-4 1-chloroacetophenone 
• 135056-36-9 (3-butyl-oxiranyl)-phenyl-methanone 

Downstream Products

• 64235-53-6 (E)-1-phenyl-2-hepten-1-one 
• 497933-11-6 (Z)-2-chloro-1-phenylhept-2-en-1-one 

Relevant academic research and scientific papers

An efficient synthesis of (E)-α,β-unsaturated ketones and esters with total stereoselectivity by using chromium dichloride

(E)-α,β-Unsaturated ketones 1 or esters 2 can be obtained with complete stereoselectivity by reaction of different 2-chloro-3-hydroxy ketones 3 or esters 4 and CrCl2. A comparative study of the results of synthesis of ketones 1 with CrCl2 or samarium is performed. A mechanism to explain both β-elimination reactions has been proposed.

Synthesis of (E)-α,β-unsaturated ketones with total or high diastereoselectivity by using samarium diiodide or triiodide

(E)-α,β-Unsaturated ketones are obtained by reaction of α-chloro-β-hydroxy ketones with samarium diiodide or with samarium triiodide with total or high diastereoselectivity and in good yield.

Preparation of (Z)-α-chloro-α,β-unsaturated ketones with total or high diastereoselectivity

(Z)-α-Chloroenones are obtained by reaction of α-chloro-β-hydroxyketones with acetic anhydride, pyridine and 4-dimethylaminopyridine with total or high diastereoselectivity and in high yield.