540481-48-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis
Zeng, Wenbin,Miao, Weimin,Kabalka, George,Puil, Michael Le,Biggerstaff, John,Townsend, David
body text, p. 6429 - 6432 (2009/04/06)
To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.
