540483-09-8

Basic information

• Product Name: Phosphonic acid, (3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-, diphenyl ester
• CAS NO: 540483-09-8
• Molecular Formula: C17H13N4O4P
• Molecular Weight: 368.288
• Mol File: 540483-09-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-, diphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-, diphenyl ester(540483-09-8)
• EPA Substance Registry System: Phosphonic acid, (3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-, diphenyl ester(540483-09-8)

Safety Data

• Hazardous Substances Data: 540483-09-8(Hazardous Substances Data)

Upstream product

• 39968-33-7 1-hydroxy-7-aza-benzotriazole 
• 2524-64-3 chlorophosphoric acid diphenyl ester 

Downstream Products

• 154561-21-4 Z-Aib-OAt 

Relevant articles and documents

Organophosphorus and Nitro-Substituted Sulfonate Esters of 1-Hydroxy-7-azabenzotriazole as Highly Efficient Fast-Acting Peptide Coupling Reagents

Organophosphorus esters 9, 10, 14, and 15 prepared via reaction of diethyl- and diphenylphosphoryl chloride, di(o-tolyl)phosphinyl chloride, and 2,8-dimethylphenoxaphosphinyl chloride with HOAt are excellent coupling reagents for peptide synthesis which are generally superior to their uronium/guanidinium analogues and HOBt- or HODhbt-derived phosphate ester counterparts in minimizing loss of configuration during segment coupling. The phosphinyl analogues are more shelf-stable than the phosphoryl systems. The new reagents have been tested in segment couplings leading to two tripeptides (20, 21) and a hexapeptide 22. Outstanding utility is also shown for the solid-phase assembly of the ACP decapeptide. Similar results were obtained with the 2- and 4-nitro- and 2,4-dinitrophenylsulfonyl esters derived from HOAt.