540496-36-4

Upstream product

• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 1152-61-0 N-Cbz-L-Asp 
• 50903-49-6 2(S)-((tert-butoxycarbonyl)amino)-3-methyl-butyric acid 2,3,4,5,6-pentafluorophenyl ester 
• 540496-34-2 (S)-(2-oxo)oxazolidine-4-acetic acid benzyl ester 

Relevant academic research and scientific papers

Introduction of 4(S)-oxazolidineacetic acid, 2-oxo (D-Oxac) motif in a polypeptide chain: Synthesis and conformational analysis

A four step synthesis of 4(S)-oxazolidineacetic acid, 2-oxo benzyl ester (D-Oxac-OBn) from L-Asp-OH in 45% overall yield is reported. The formation of by-products is completely avoided, by microwave irradiation and by the use of caesium carbonate as base. Moreover the synthesis and IR and 1H NMR conformational analysis of the tetramers Boc-L-Val-D-Oxac-L-Ala-OBn and Boc-L-Val-D-Oxac-Aib-L-Ala-OBn in solution is reported.