540508-63-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 540508-41-6 (2S,3R)-3-[4-(1-Hydroxy-2-nitro-ethyl)-phenoxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 540508-30-3 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-cyano-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 540508-37-0 (2S,3R)-3-(4-Cyano-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 540508-35-8 (2S,3R)-3-(4-Cyano-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 540508-39-2 (2S,3R)-3-(4-Formyl-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 123278-55-7 (4R,5S)-5-<(1,1-dimethylethyl)dimethylsilyl>oxymethyl-4-hydroxy-1-<(1,1-dimethylethoxy)carbonyl>-pyrrolidin-2-one 
• 128836-20-4 tert-butyl (2R,3R)-2-[(tert-butyldimethylsiloxy)methyl]-3-hydroxypyrrolidine-1-carboxylate 

Downstream Products

• 540508-43-8 3-{4-[2-amino-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

Studies toward a synthesis of C3-epimauritine D: Construction of the macrocycle

We successfully synthesized a 14-membered cyclic enamide of C3-epimauritine D from the cis-2,3-pyrrolidinediol derivative. Treatment of the pyrrolidinediol with nitrobenzonitrile in an SNAr reaction efficiently installed the desired aryl-alkyl ether linkage on the N-heterocyclic system. Macrocyclization was successfully achieved by the use of TFFH as the peptide coupling reagent in the presence of HOAt.