540513-50-6

Basic information

• Product Name: C₁₈H₁₆N₆O₂S₂
• CAS NO: 540513-50-6
• Molecular Weight: 412.496
• Mol File: 540513-50-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆N₆O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆N₆O₂S₂(540513-50-6)
• EPA Substance Registry System: C₁₈H₁₆N₆O₂S₂(540513-50-6)

Safety Data

• Hazardous Substances Data: 540513-50-6(Hazardous Substances Data)

Upstream product

• 3268-74-4 2-chloro-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 

Relevant articles and documents

Synthesis and analgesic activity of some acetamide derivatives

In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1- substituted-1H-tetrazol-5-yl)thio]acetamide derivatives were obtained by the nucleophilic substitution reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with appropriate tetrazol-5-thioles. The chemical structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR and FAB +-MS spectral data and elemental analyses. The prepared compounds were investigated for their potential analgesic properties against thermal, mechanical and chemical nociceptive stimuli using hot-plate, tail-clip and acetic acid-induced writhing tests, respectively. The assessment of motor coordination was carried out using Rota-Rod test. Tested compounds applied at 100mg/kg doses caused significant decrease in acetic acid-induced writhing responses and increase in hot-plate and tail-clip latencies. None of the compounds exhibited destructive effect on motor coordination of the mice in Rota-Rod performance.