54052-76-5

Upstream product

• 2158-04-5 (2-phenylethyl)urea 
• 64-04-0 phenethylamine 

Downstream Products

• 1258496-04-6 7-(2-oxopyrrolidin-1-ylmethyl)-1-phenethyl-5,5-bis(trifluoromethyl)-5,8-dihydro-1H-pyrimido[4,5-d]pyrimidine-2,4-dione 
• 1219581-36-8 1-(2-phenylethyl)-5-(pyrimidin-2-ylamino)-5-trifluoromethyl-5,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-2,4,6(3H)-trione 
• 1282121-02-1 N-(2-methoxyphenyl)-2,4,7-trioxo-1-(2-phenylethyl)-1,2,3,4,5,6,7,8-octahydropyrido[2,3-d]pyrimidine-5-carboxamide 
• 1282095-44-6 N-(2-fluorophenyl)-2,4,7-trioxo-1-(2-phenylethyl)-1,2,3,4,5,6,7,8-octahydropyrido[2,3-d]pyrimidine-5-carboxamide 
• 1352413-59-2 N-phenyl-2,4,7-trioxo-1-(2-phenylethyl)-1,2,3,4,5,6,7,8-octahydropyrido[2,3-d]pyrimidine-5-carboxamide 
• 1240508-20-6 N-{1-(2-phenylethyl)-2,4,6-trioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide 

Relevant academic research and scientific papers

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

XANTHINE DERIVATIVES AS A2B ADENOSINE RECEPTOR ANTAGONISTS

Disclosed are compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.

A2B adenosine receptor antagonists

Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.

A novel ring closure reaction for the preparation of 6-aminouracils with an α-branched 1-substituent

The preparation of 6-aminouracil derivatives is described involving a novel, silicon-promoted ring closure reaction. Condensation of N-substituted urea with cyanoacetic acid yields cyanoacetylureas, which are heated in hexamethyldisilazane/trimethylchlorosilane to afford N-substituted 6- aminouracils. Previously unaccessible derivatives bearing an α-branched 1- substituent, including 6-amino-1-(1-phenylethyl)uracil were obtained.