54063-54-6

Basic information

• Product Name: Reproterol
• Synonyms: Reproterol;7-[3-[(β,3,5-Trihydroxyphenethyl)amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;7-[3-[[2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]theophyline;D-1959;1,2,3,6-Tetrahydro-1,3-dimethyl-7-(3-((beta,3,5-trihydroxyphenethyl)amino)propyl)-2,6-purindion;13055-82-8 (Mono-hydrochloride);7-(3-((2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl)amino)propyl)theophylline;7-(3-((beta,3,5-Trihydroxyphenethyl)amino)propyl)theophylline
• CAS NO: 54063-54-6
• Molecular Formula: C₁₈H₂₃N₅O₅
• Molecular Weight: 389.41
• EINECS: 258-956-1
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 54063-54-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 723.4°Cat760mmHg
• Flash Point: 391.3°C
• Appearance: /
• Density: 1.47g/cm³
• Storage Temp.: Refrigerator
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 9.40±0.10(Predicted)
• CAS DataBase Reference: Reproterol(CAS DataBase Reference)
• NIST Chemistry Reference: Reproterol(54063-54-6)
• EPA Substance Registry System: Reproterol(54063-54-6)

Safety Data

• Hazardous Substances Data: 54063-54-6(Hazardous Substances Data)

Usage

Description

Reproterol, also known as Reproterol Hydrochloride, is a synthetic medication belonging to the class of β2 adrenoceptor agonists. It is an off-white solid with chemical properties that allow it to interact with specific receptors in the body, leading to its therapeutic effects. Reproterol is primarily used for treating respiratory conditions, particularly asthma, by promoting bronchodilation and reducing inflammation.

Uses

Used in Pharmaceutical Industry:
Reproterol is used as a bronchodilator for the treatment of asthma. It works by stimulating β2 adrenoceptors in the lungs, leading to the relaxation of smooth muscle cells and subsequent widening of the airways. This helps alleviate the symptoms of asthma, such as shortness of breath, wheezing, and coughing.
Additionally, Reproterol may be used in other respiratory conditions where bronchodilation is required, such as chronic obstructive pulmonary disease (COPD) and exercise-induced asthma. However, it is important to note that the use of Reproterol should be under the guidance of a healthcare professional, as it may have potential side effects and contraindications.

InChI:InChI=1/C18H23N5O5/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3

Relevant articles and documents

Combined doses

The present invention discloses a method and a pharmaceutical dry powder combined dose for the prophylaxis or treatment of a respiratory disorder in a mammalian host by inhalation of a metered dry powder combined dose of finely divided dry medication powders. At least one dry powder medicament is selected from a first group of bronchodilating medicaments and at least one dry powder medicament from a second group of anti-inflammatory medicaments. A metered dry powder medicinal combined dose comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments is prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined dose and the medicinal combined dose is introduced into an adapted inhaler device for a generally simultaneous delivery of the medicinal combined dose during the course of a single inhalation by a user, such that the delivered medicinal combined dose is composed of a high proportion of mixed de-aggregated fine particles of the selected medicaments, whereby an desired therapeutic or treating effect to the user is achieved.

Synthesis of bronchospasmolytically effective β phenylethyl aminoalkyl xanthines

New theophylline and theobromine derivatives are synthesized from the β phenylethylaminoalkyl xanthines, whose phenyl substituent is substituted by one or two hydroxyl groups and partially also by other substituents. Different methods of synthesis are described, among them the production of the bronchospasmolytic 7 (3 [2 (3,5 dihydroxyphenyl) 2 hydroxy ethylamino] propyl) theophylline (reproterol . HCl).