54063-56-8 Usage
Originator
Sulocton,Cooper,Switz.,1978
Uses
Vasodilator (peripheral).
Manufacturing Process
(a) To 28.7 g of α-bromo-4-isopropylthiopropiophenone (0.1 mol) in 100 ml of
isopropanol there are rapidly added 14.2 g of n-octylamine while stirring, and
then the mixture is brought to 80°C for 1 hour. The solvent is evaporated
under vacuum, the residue is diluted with 1 liter of ether and is left to stand
overnight in the refrigerator. The precipitate obtained is filtered and dried.
There are thus obtained 25 g of α-n-octylamino-4-isopropylthiopropiophenone
hydrobromide. Yield: 60%; melting point: 162°C to 164°C.(b) 41.6 g of the preceding product (0.1 mol) in 200 ml of methanol are
cooled in an ice bath to 0°C. There is added drop by drop while stirring a
solution of 4.1 g of NaBH4 in 50 ml of water and 2 ml of 5% NaOH. Next, the
mixture is stirred for 2 hours at room temperature. The methanol is
evaporated under vacuum, diluted with 200 ml of water and extracted with
methylene chloride or ether. The organic phase is dried on MgSO4 and the
solvent is evaporated under vacuum. The oily residue obtained solidifies
rapidly and is recrystallized in pentane. 33.2 g are thus obtained. Yield: 90%;
melting point: 62°C to 63°C.
Therapeutic Function
Spasmolytic, Vasodilator
Check Digit Verification of cas no
The CAS Registry Mumber 54063-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,0,6 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 54063-56:
(7*5)+(6*4)+(5*0)+(4*6)+(3*3)+(2*5)+(1*6)=108
108 % 10 = 8
So 54063-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3
54063-56-8Relevant academic research and scientific papers
Alkyl and cycloalkylthiophenylalkylaminoalkanols, their salts and the preparation thereof
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, (2008/06/13)
Amino-alcohols of the formula STR1 wherein R1 represents either a linear or branched chain alkyl radical having 1 to 4 carbon atoms, or a cycloalkyl radical having 5 or 6 carbon atoms; R2 represents a lower alkyl radical having 1 or 2 carbon atoms; R3 represents a linear or branched chain alkyl radical having 3 to 10 carbon atoms which radical is optionally substituted by phenyl; R4 represents hydrogen, or, together with R3 and the adjacent nitrogen atom, a heterocyclic nucleus of the piperidine type and the corresponding non-toxic salts of said amino-alcohols; preparation of the above and their use as antispasmodic, peripheral vasodilatory and anti-hypertensive agents and as an agent having a protective activity against anoxia of the myocardium.
