54064-42-5Relevant academic research and scientific papers
Synthesis of novel 17-(5′-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro Dedicated to Professor Irén Vincze on the occasion of her 85th birthday
Schneider, Gyula,G?rbe, Tamás,Mernyák, Erzsébet,W?lfling, János,Holczbauer, Tamás,Czugler, Mátyás,Sohár, Pál,Minorics, Renáta,Zupkó, István
, p. 153 - 165 (2015)
The regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of 3-methoxyestrane 17α- and 17β-azide epimers (3 and 5) with different terminal alkynes afforded novel 1,4-substituted triazolyl derivatives (8a-f and 11a-f). If the Ph3P in the clas
DERIVATIVES OF STEROID BENZYLAMINES, HAVING AN ANTIPARASITIC ANTIBACTERIAL, ANTIMYCOTIC AND/OR ANTIVIRAL ACTION
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Paragraph 0368, (2013/10/22)
The present invention relates to compounds derived from steroids of the general formula (I) wherein L represents a linker and R# represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis a
SYNTHESIS OF SOME EPITESTOSTERONE ANALOGUES
Chodounska, Hana,Slavikova, Barbora,Kasal, Alexander
, p. 435 - 443 (2007/10/02)
11β-Hydroxyandrost-4-ene-3,17-dione (III) was converted into a potential metabolite of epitestosterone - 11β,17α-dihydroxyandrost-4-en-3-one (II) in 5 steps, including the inversion of configuration of a 17β-hydroxy group.This inversion was not feasible in the preparation of the analogues X, XIV, XX, and XXII, where the 17α-hydroxy group was introduced first and only then was the rest of molecule modified.
Steroids, XXXVIII. Neighbouring Group Participation, IX. Preparation of 16α-Hydroxymethyl-3-methoxyestra-1,3,5(10)-trien-17α-ol and Solvolysis Investigations
Schneider, Gyula,Hackler, Laszlo,Sohar, Pal
, p. 679 - 684 (2007/10/02)
Solvolysis of the p-toluenesulfonate 1d in acetic acid and in dimethyl sulfoxide yields 5b with inversion at C-17.The conversion can be explained by a neighbouring group participation characterized by the general symbol (AcO-6).In order to confirm the participation of the 16α-acetoxymethyl group in 1d, comparative solvolytic investigations were carried out with the toluenesulfonate 9.
