5407-84-1

Usage

Uses

Used in Pharmaceutical Industry:
(1-phenylcyclopentyl)acetonitrile is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its versatile structure allows it to participate in multiple chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
As a compound with a distinct structure, (1-phenylcyclopentyl)acetonitrile serves as a valuable reagent in organic chemistry research. It is employed in various chemical transformations to explore new reaction pathways and synthesize novel organic compounds.
Used in Chemical Synthesis:
The presence of the acetonitrile group in (1-phenylcyclopentyl)acetonitrile makes it a versatile reagent for a wide range of chemical reactions. It is used in the synthesis of various organic compounds, including those with potential applications in materials science, agrochemicals, and other industries.

Upstream product

• 773837-37-9 sodium cyanide 
• 5407-83-0 ethyl 2-cyano-2-cyclopentylideneacetate 
• 100-58-3 phenylmagnesium bromide 
• 100611-61-8 (1-phenyl-cyclopentyl)-acetaldehyde 
• 59115-90-1 1-hydroxymethyl-1-phenylcyclopentane 
• 21573-69-3 1-phenyl-1-cyclopentanecarboxaldehyde 
• 77-57-6 1-phenyl-1-cyclopentanecarbonitrile 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 1616924-72-1 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide 
• 1616922-83-8 5-(benzyloxy)-6-hydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylic acid 
• 1616922-81-6 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616922-79-2 2-(1-phenylcyclopentyl)acetamidine hydrochloride 
• 1616924-78-7 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](4-fluorobenzyl)amide 
• 1616924-76-5 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide 
• 1616924-69-6 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](2,2-dimethylpropyl)amide 
• 1616924-66-3 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)oxetan-3-ylamide 
• 1616924-65-2 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]oxetan-3-ylamide 
• 1616924-61-8 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclobutylamide 
• 1616924-57-2 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopentylamide 
• 1616924-55-0 9-benzyloxy-2-cyclopropyl-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-54-9 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropyl(2-hydroxyethyl)amide 
• 1616924-53-8 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylamide 

Relevant academic research and scientific papers

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.

One-Pot Preparation of C1-Homologated Aliphatic Nitriles from Aldehydes through a Wittig Reaction under Metal-Cyanide-Free Conditions

A one-pot protocol to obtain C1-homologated aliphatic nitriles was achieved by treating aromatic and aliphatic aldehydes with the (methoxymethyl)triphenylphosphonium ylide followed by hydrolysis of the resulting methyl vinyl ethers with pTsOH (Ts = para-toluenesulfonyl) and treatment with molecular iodine and aqueous ammonia under metal cyanide free conditions. Neopentyl-type nitriles, which could not be obtained by conventional methods that involved conversion of the neopentyl alcohol into a tosylate and treatment with metal cyanide, were successfully obtained by using the present method.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes providing nitriles

(Chemical Equation Presented) Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes in the presence of 9,10-dihydroanthracene and potassium carbonate proceeds to give saturated nitriles via C-C bond fission at the sterically more hinde