540731-23-5Relevant academic research and scientific papers
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor
Billot, Xavier,Chateauneuf, Anne,Chauret, Nathalie,Denis, Danielle,Greig, Gillian,Mathieu, Marie-Claude,Metters, Kathleen M.,Slipetz, Deborah M.,Young, Robert N.
, p. 1129 - 1132 (2007/10/03)
Analogues of PGE2 wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP4 receptor. An optimized compound (19a) shows high potency and agonist efficacy at the EPsu
