540737-40-4Relevant articles and documents
AZOLE COMPOUND AND MEDICINAL USE THEREOF
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Page 31-32, (2010/02/08)
The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is -COOR7, -X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is -(CH2)m-X- (X is -N(R8)-, -C(R9)(R10)-, -CO- or -CO-N(R8)-); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is -(Y)s1-(A2)s-Z (Y is -O-, -S(O)t-, -N(R13)-, -N(R14)-CO-, -N(R14)-SO2-, -SO2-N(R14)- and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.